REPUBLIKA.CO.ID, DAMASCUS -- A car bomb went off in the predominantly Kurdish city of Al-Qamishli in northeastern Syria on Saturday, killing at least five people, pro-government Sama TV reported.

The car bomb hit a checkpoint of the Kurdish People's Protection Units, or YPG, at the al-Hilaliyeh roundabout in Al-Qamishli in the northeastern province of al-Hasakah.

The state news agency SANA reported the explosion, without giving a death toll.

Meanwhile, the Syrian Observatory for Human Rights said a powerful explosion was heard in the Hilaliyeh district west of Al- Qamishli, adding that the preliminary information indicated the presence of several causalities.

The Kurds, who make up 15 percent of Syria's 23 million inhabitants with most living in the north of the embattled country, have been trying to keep their areas away from military operations and retain the kind of "autonomy."

In 2012, Syrian troops withdrew from most of the Kurdish areas, and Kurdish militia took over local security. The government, however, is still in control of vital areas in the city of Qamishli and the al-Hasakah province.

Following the surge of the IS militants in July 2014 and their capture of Kurdish areas in northern Syria, the U.S.-led coalition begun to help the Kurds in their battles against the extremists.

Last month, the Kurds voted in favor of establishing a federal region, which would include the areas in northern Syria on a triangular basis of the predominantly Kurdish strongholds of Kobani, Afreen and the al-Jazeera region.

A car bomb also went off in Syria's eastern province of Deir al-Zour on Saturday, leaving unknown losses, pro-government Sham FM radio reported.

The car exploded near the Furat al-Sham Hotel in the city of Deir al-Zour, said the report, providing no further details.

Meanwhile, the Syrian Observatory for Human Rights said intense battles raged on Saturday between the Syrian army and the Islamic State (IS/ISIS) militants.

The UK-based watchdog said 26 Syrian soldiers were killed when the IS militants infiltrated the areas southwest of Deir al-Zour, after which the militants captured a hospital.

The Syrian army has besieged the hospital amid ongoing clashes.

A military source said that the Syrian warplanes have struck the positions of IS in the vicinity of the Deir al-Zour airbase, which has also been a target of the recent IS attacks.